Following are metabolic antianginal agents
Glucose insulin potassium (GIK) infusion
Trimetazidine
Reduces the rate of FFA oxidation, with a concomitant increase in glucose oxidation rates by inhibiting enzyme LC 3-KAT(long chain 3 keto acyl coenzyme A thiolase), which is a crucial enzyme in beta oxidation pathway.
Ranolazine
Similar to trimetazidine. Acts as a partial fatty acid oxidation inhibitor (only during myocardial ischemia)& stimulates glucose oxidation
Perhexiline
It acts by shifting myocardial substrate utilization from fatty acids to carbohydrates through inhibition of CPT 1
L-Carnitine
Protects cardiac cells against oxidative stress, hypoxia & ischemia. It decreases toxic coenzyme A derivatives.
Etomoxir
Dichloroacetate
