Indications for thrombolysis
STE 2mm or > in precordial leads
STE 1mm or>in Inferior leads
Fresh LBBB
Posterior Myocardial infarction
Contraindication for thrombolysis
H/O ICH
AVM, Aneurysms
Intracranial tumours
Ischemic stroke <3 months
Aortic dissection
Major Trauma with in 3 months
High BP, SBP>180 mm DBP >110mm
Bleeding diathesis
Previous STK use > 5days & <2 yr
>12 hrs after onset of pain
Administration
1.5 million IU STK in 100 ml NS over 1hour
Inj Avil + Efcorlin is given prior
ECG & BP monitoring
Adverse reactions
Life threatening ICH
Hypotension
Bleeding from puncture sites
Allergy
Signs of therapeutic Efficacy
Symptomatic improvement
ECG Change
Late diastolic VPCs
AIVR
Fall of STE
Early peaking & fall in enzyme levels
STE -ST segment elevation
STK-Streptokinase
ICH-Intracerebral hemorrhage
VPC-Ventricular premature contractions
IU-International unit
