What are the Signs and Symptoms of Cushing’s Syndrome

Cushing syndrome produce changes in body fat,skin,bone,muscle,resproductive system,cardiovasular and blood.

Changes in the body fat

•          Body fat Weight gain
•        Central obesity
•          Rounded face
•          Fat pad on back of neck (“buffalo hump”)

Changes in the Skin

•  Facial plethora
•          Thin and brittle skin
•          Easy bruising,
•          Broad and purple stretch marks,
•          Acne
• ·        Hirsutism

Changes in Bone

•         Osteopenia
•          Osteoporosis (vertebral fractures),
•         Decreased linear growth in children

Changes in muscle

•          Muscle Weakness
•          Proximal myopathy (prominent
• ·        Atrophy of gluteal and upper leg muscles

Changes Metabolism

• Glucose intolerance/diabetes
• Dyslipidemia
• Changes in the Cardiovascular system
• Hypertension
• Hypokalemia,
• Edema
• Atherosclerosis 

Reproductive system changes

• Decreased libido,  amenorrhea in women

Blood and immune system changes

• Increased susceptibility to infections
• Increased white blood cell count
• Eosinopenia,
• Hypercoagulation with increased risk of deep vein thrombosis and pulmonary embolism

Central nervous system changes

• Irritability
• Emotional lability
• Depression,
• Cognitive defect and paranoid psychosis