Structure:
Myelin is composed of multiple layers of cell membrane wrapped around the axon, forming a compact and highly organized structure. The myelin sheath is interrupted by small gaps called nodes of Ranvier, which allow for the rapid transmission of nerve impulses along the axon. The myelin sheath is also enriched in specific proteins, including myelin basic protein (MBP), which are important for its structure and function.
Function:
The primary function of myelin is to insulate the axon and improve the speed and efficiency of nerve conduction. The myelin sheath reduces the loss of electrical signals along the axon, allowing nerve impulses to travel faster and over longer distances. Myelin is essential for normal neurological function, and disorders that affect myelin can lead to a range of neurological deficits.
Formation:
Myelin is formed during development by oligodendrocytes in the CNS and Schwann cells in the PNS. These cells extend multiple processes that wrap around the axon, forming the compact myelin sheath. Myelin formation is a complex and highly regulated process, involving the interaction of multiple signaling pathways and molecular cues.
Neurological disease associated with myelin and MBP:
Disorders that affect myelin can lead to a range of neurological diseases, including multiple sclerosis (MS), leukodystrophies, and Charcot-Marie-Tooth disease (CMT). In MS, for example, the immune system attacks and destroys the myelin sheath, leading to the formation of scar tissue and neurological deficits. MBP is a major protein component of myelin, and mutations in the MBP gene have been associated with several neurological diseases, including MS and leukodystrophies. In these disorders, the mutations in the MBP gene can lead to abnormal myelin formation or degradation, resulting in neurological deficits. Understanding the role of myelin and MBP in these diseases is important for the development of new treatments and therapies to improve neurological function.
