Definition of NAFLD
This is a condition where patients having hepatic steatosis with or without inflammation and fibrosis, without any secondary causes of hepatic steatosis.
Following are the criteria for diagnosing nonalcoholic fatty liver disease
Imaging or biopsy should demonstrate hepatic steatosis.
Significant alcohol consumption should be excluded.
Other causes of hepatic steatosis should be excluded.
What are the stages of NAFLD?
It include progression from steatosis, steatohepatitis to cirrhosis of liver
Steatosis ( Fatty liver )– NAFLD
Steatohepatitis – NASH
Cirrhosis
What are the disorders associated with NAFLD
Obesity
Systemic Hypertension
Hyperlipidemia
Insulin resistance or overt diabetes
PCOD
OSAS
Hypothyroidism
Hypopituitarism and hypogonadism
A family history of steatohepatitis or cryptogenic cirrhosis is also implicated as a risk factor
Prevalence of NAFLD
It is seen in 10-24% of general population.
2.6% of pediatric population have NAFLD.
It is the most common cause of cryptogenic cirrhosis
2/3rd of the obese patients have NASH.
90% of morbidly obese patients have NASH.
