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Hypopigmentation of skin

Generalised absence of skin pigmentation is seen in Albinism 
Following are the syndromes with albinism
Chediac higashi syndrome also called as phagocytic deficiency disease
Phenylketonuria a condition characterised by inborn error of metabolism
Patchy absence of skin pigmentation may be due to Vitiligo which is seen in 
  • Idiopathic cases
  • Autoimmune disease
  • Thyroid disease
  • Pernicious anemia
In the presence of vitiligo always rule out immune causes in that patient
What are the causes of Hypopigmented Lesions
  • Early vitiligo
  • Leukoderma-early
  • Hansen's disease
  • Nevus anemicus
  • Leafy macules-tuberous sclerosis
  • Tinea versicolor
  • Pityriasis alba
Circumscribed hypopigmented lesions of the skin may be seen in Hansens disease ( Tuberculoid or Borderline Tuberculoid types) and Tinea versicoior.